Loss of spleen, loss of limbs, lymphedema, infertility, heart problems, weakening of the heart muscle (shortness of breath, dizziness, and swollen hands or feet, coronary artery disease (chest pain and shortness of breath), arrhythmia, hypertension (high blood pressure that often causes organ damage), lung problems (loss of lung function, inflammation of the lungs, difficulty breathing), endocrine system problems (risk of hormone changes and imbalance, early menopause in women caused by cancer treatment with severe symptoms including changes in mood or sexual desire, hot flashes, osteoporosis, and bladder control problems), male menopause (change in sexual desire, hot flashes, osteoporosis – may require hormone therapy for prostate cancer or surgery to remove the testicles), infertility in men and women, thyroid problems, bone, joint, and soft tissue problems (thinning of the bones called osteoporosis, joint pain, rheumatologic issues), brain, spinal cord, and nerve problems (hearing loss, increased risk of stroke, damage to the nerves outside the brain and spinal cord called peripheral neuropathy), learning, memory, and attention difficulties (cognitive problems and trouble processing information), dental and oral health problems (long-term dental problems, changes in tooth development, gum disease, lower saliva production causing a dry mouth), vision problems (clouding of the eye that affects vision called cataracts), digestion problems (changes in how a person digests food, tissue scarring, long-term pain, intestinal problems including chronic diarrhea that reduces the body’s ability to absorb nutrients), emotional problems and post traumatic stress disorder, secondary cancers, bone marrow stem cell damage (increases the risk of acute leukemia or myelodysplasia), fatigue (constant feeling of physical, emotional, or mental tiredness - the most common side effect of cancer treatment – can persist for months or years after finishing treatment).